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KMID : 0624620190520120671
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BMB Reports
2019 Volume.52 No. 12 p.671 ~ p.678
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The Yin and Yang of RNA surveillance in B lymphocytes and antibody-secreting plasma cells
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Lambert Jean-Marie
Srour Nivine
Delpy Laurent
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Abstract
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The random V(D)J recombination process ensures the diversity of the primary immunoglobulin (Ig) repertoire. In two thirds of cases, imprecise recombination between variable (V), diversity (D), and joining (J) segments induces a frameshift in the open reading frame that leads to the appearance of premature termination codons (PTCs). Thus, many B lineage cells harbour biallelic V(D)J-rearrangements of Ig heavy or light chain genes, with a productively-recombined allele encoding the functional Ig chain and a nonproductive allele potentially encoding truncated Ig polypeptides. Since the pattern of Ig gene expression is mostly biallelic, transcription initiated from nonproductive Ig alleles generates considerable amounts of primary transcripts with out-of-frame V(D)J junctions. How RNA surveillance pathways cooperate to control the noise from nonproductive Ig genes will be discussed in this review, focusing on the benefits of nonsense- mediated mRNA decay (NMD) activation during B-cell development and detrimental effects of nonsense-associated altered splicing (NAS) in terminally differentiated plasma cells.
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KEYWORD
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Immunoglobulin, Nonsense-associated altered splicing (NAS), Nonsense-mediated mRNA decay (NMD), Plasma cells, RNA surveillance
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